New Discovery of Skin Whitening Cosmetics: CMU Research Center for Chinese Herbal Medicine Published Research Findings in Redox Biology

Date:May 25, 2021

Chinese Version


Good news for people who love skin care! The research team of CMU Research Center for Chinese Herbal Medicine discovered that Pterostilbene, a natural derivative of resveratrol, can induce autophagy in melanocytes to inhibit melanin production and exhibit whitening effects. Their study “The in vitro and in vivo depigmenting activity of pterostilbene through induction of autophagy in melanocytes and inhibition of UVA-irradiated α-MSH in keratinocytes via Nrf2-mediated antioxidant pathways” was published in the August 2021, issue of Redox Biology. It proved that pterostilbene is a safe and effective Chinese herbal medicine that can be applied in cosmetics. Pterostilbene is a good natural antioxidant that is lipophilic and can be used for oral administration.

 

Tanning occurs when UV rays penetrate into the skin to accelerate the synthesis of free radicals and melanin. As UV rays irradiate melanocytes, they will stimulate tyrosinase to form melanin. On the other hand, autophagy is the process in which cells decompose organelles or substances with abnormal gaining or loss of function. Melanosomes in melanocytes are responsible for the synthesis and storage of melanin. The key finding of this research is that pterostilbene can induce the autophagy in melanocytes to degrade melanosome and inhibit the production of melanin.

 

In recent years, cosmetic companies are using Chinese herbal medicine and natural nutrients to produce whitening effects. However, most natural nutrients cannot easily pass through the stratum corneum and skin cell membrane. Therefore, with the ability to make skin cells produce antioxidant substances and effectively reduce tanning caused by UV rays, pterostilbene is a highly potential cosmetic whitening product.


Photos:


	Professor Hsin-Ling Yang and Professor You-Cheng Hseu of the research team

Professor Hsin-Ling Yang and Professor You-Cheng Hseu of the research team


	Redox Biology Journal

Redox Biology Journal

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