Tannic Acid Can Effectively Suppress SARS-CoV-2: CMU Research Team Publish Anti-Pandemic Research Findings in American Journal of Cancer Research
Date：January 25, 2021
The research team of China Medical University (CMU) led by President Mien-Chie Hung have been putting a lot of effort in the research for anti-pandemic. Their latest research “Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease” was published on American Journal of Cancer Research. It first revealed that tannic acid can inhibit the main protease of SARS-CoV-2 and the transmembrane protease serine 2 (TMPRSS2), which can further inhibit the virus’ ability to enter the host’s cell. This research attracted great attention from the international academic fields, and have shown that tannic acids is a potential candidate in developing anti-COVID-19 treatment.
President Mien-Chie Hung said that the main protease of the novel coronavirus plays an important role in the spread of the virus in the host. In addition, TMPRSS2 is a serine protease for therapeutic target that also plays a key role in novel coronavirus. In view of this, the research team applied the concept of precision medicine for targeted cancer treatment, to develop the potential drug for COVID-19, and provide new strategies for COVID-19 treatment.
By looking into the natural compounds found in common foods and explore if they are effective in fighting against coronavirus, the research team screened a number of natural compounds and found that tannic acid is a high potential inhibitor that can fight against the novel coronavirus and TMPRSS2. They found that in molecular experiment analysis, it is confirmed that tannic acid and these two proteins can form a stable complex structure, and further inhibit the activity of these proteins. In functional test, tannic acid is also shown to inhibit virus from entering cells.
The pandemic of COVID-19 is still severe. China Medical University has been showing a research university’s social responsibility by developing cutting-edge medical research and trying to find effective treatments.