The Pioneer of Tumor Suppressors- Chancellor Wen-Hwa Lee was Honored the Academician of TWAS

Date: January 30, 2018

Chancellor Wen-Hwa Lee, also the world-famous Cancer Biologist, was honored the Academician of The World Academy of Sciences for the Advancement of Science in Developing Countries (TWAS)- an association established in 1983 that works to support sustainable prosperity through research, education, policy and diplomacy.


Chancellor Lee is a pioneer in the field of tumor suppressors in cancer research. He discovered the first human tumor suppressor gene (TSG)- Retinoblastoma gene in 1987. He is currently an Academician of Academia Sinica, Taiwan; a fellow of the National Academy of Inventors, USA and the Chancellor of China Medical University.


Chancellor Lee’s research team has published a paper on “Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate”. His research shows that β-hydroxybutyrate is secreted by MGDAs and is required to enhance breast cancer cells malignancy in vitro. Consistently, β-hydroxybutyrate is sufficient to promote tumorigenesis of a mouse xenograft model of MCT2-expressing breast cancer cells. These results suggest that adipocytes promote malignancy of MCT2-expressing breast cancer via β-hydroxybutyrate potentially by inducing the epigenetic upregulation of tumour-promoting genes.


Chancellor Wen-Hwa Lee was Honored the Academician of TWAS
Chancellor Wen-Hwa Lee