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Professor Jing-Gung Chung and Associate Professor Jai-Sing Yang have been awarded the “Thomson Reuters Taiwan Research Front Awards 2011”

Date: November 15, 2011

The “Thomson Reuters Taiwan Research Front Awards 2011” is founded by international business and professional information providers Thomson Reuters. The awards are based on the most highly cited research papers in the past five years. Scholarly research publications were analyzed by calculating their level of influence in specific scientific fields. Eleven scientists in Taiwan involved in seven newly emerging fields were presented with awards this year. The most highly cited research paper was published by Professor Jing-Gung Chung (Department of Biological Science and Technology; Dean of Academic Affairs) and Associate Professor Jai-Sing Yang (Department of Pharmacology, College of Medicine) of China Medical University.   

Professor Chung indicated that organic sulfur compounds in garlic can efficiently inhibit the growth of colon cancer cells. Professor Chung and his research team showed how compounds from garlic result in tumor cell cycle arrest and cause cell death. This finding provides useful information for drug development against colon cancer. Professor Chung said that his team is conducting in vitro experiments to identify compounds that can efficiently inhibit tumor angiogenesis at low concentrations. These compounds should be beneficial for the development of anti-colon cancer drugs.

Professor Chung’s laboratory uses a range of modern cell and molecular biology techniques, including determination of cell survival/death, examination of cell morphology changes by phase microscopy, microscopic techniques using fluorescence/DAPI staining, analysis of cell cycle and apoptosis by flow cytometry, quantification of gene expression by PCR and real-time PCR, analysis of nuclear and cytoplasmic protein expression by Western blotting, and use of cDNA microarray and proteomics to validate the biological activity of drugs and compounds. Their research has evaluated the anti-cancer activities of numerous drugs. Results have been used to develop new drugs with potential anti-cancer abilities, and have provided the pharmaceutical industry with new directions and useful targets in this field.

His research team is currently using compounds and ingredients obtained from crude herbal extracts and natural foods with potential anti-cancer or anti-angiogenic abilities. Cell lines and animal models are used to investigate their effects on the regulation of gene expressions of human colon cancer-associated proteins. The motivation is that angiogenesis is normally involved when tumor cells develop resistance. This is a key process that promotes invasion, migration, and metastasis of tumor cells. The research team will continue to identify effective ingredients and perform analyses on the bioactivities of various Chinese herbal medicines. Their findings are expected to improve the molecular mechanisms of immune function regulation by revealing potential active ingredients and compounds with anti-cancer properties in vitro and in vivo from crude Chinese herbal extracts and natural foods.

(Chinese Version.)

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Professor Jing-Gung Chung and Associate Professor Jai-Sing Yang
           

 

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