Wen-Hwa Lee, Professor & Chancellor

Wen-Hwa Lee, Professor & Chancellor
  • Professor & Chancellor
  • China Medical University Taichung, Taiwan
  • Tel: +886-4-22057153
  • Fax: +886-4-22060248
  • E-mail:


  • B.S., National Taiwan Normal University
  • M.S., National Taiwan University
  • Ph.D., University of California, Berkeley

Research and Professional Experiences

Year Academic Experience
1984-1990 University of California, San Diego, Assistant Professor & Associate Professor
1990-1991 University of California, San Diego, Professor
1991-2003 University of Texas Health Science Center at San Antonio, Alice P. McDermott Distinguished Univ. Chair and Director
1996-2003 University of Texas Health Science Center at San Antonio, Professor and Chairman, Department of Molecular Medicine
2005-2008 University of California, Irvine, Chair, Department of Biological Chemistry, College of Medicine
2003-2013 University of California, Irvine, Donald Bren Professor of Biomedicine
2008-2010 University of California, Irvine, Professor, Department of Pharmacology
2007- National Taiwan University, Adjunct Distinguished Chair Professor, Institute of Biochemistry and Molecular Biology

Present Position

Year Current Position
2014 - Chancellor, China Medical University (Taiwan)

Professional Experiences & Awards

Year Professional Experiences & Awards
1991 A.P. McDermott Distinguished University Professor, UTHSC-SA
1991 National Institute of Health Director Lectureship
1992 Outstanding Scientific Achievement, Society of Chinese Bioscientists in America (SCBA)
1994 Academician, Academia Sinica, R.O.C.
1994 Alcon Research Award
1999 F.E. Shideman-Sterling Award, University of Minnesota
2001 Presidential Award, Society of Chinese Bioscientists in America (SCBA)
2002 Outstanding Alumni Award, National Taiwan Normal University
2002 First Class Medal, Department of Health, Taiwan
2003 Inducted Member,Texas Hall of Fame for Science, Mathematics and Technology
2003 Donald Bren Chair Professorship, Univ. California, Irvine
2010 Athalie Clarke Achievement Award, University of California, Irvine
2012 Fellow, American Association for the Advancement of Science (AAAS)


Selected Publications
Yi-Cheng Chang, Yu-Hsiang Yu, Jin-Yuh Shew ,Wei-Jei Lee, Juey-Jen Hwang, Yen-Hui Chen, Yet-Ran Chen, Pei-Chi Wei, Lee-Ming Chuang, Wen-Hwa Lee*., 2013, “Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.”, EMBO Molecular Medicine, 5(8), 1165-1179. (SCI) 
Chun-Kai Huang, Cheng-Yuan Yang, Yung-Ming Jeng, Chia-Lin Chen, Heng-Hsiung Wu, Yi-Cheng Chang, Che Ma, Wen-Hung Kuo, King-Jen Chang, Jin-Yuh Shew, and Wen-Hwa Lee*., 2013, “Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-κB-mediated antiapoptotic pathway”, Oncogene, 15 July. (SCI) 
Wei PC, Wang ZF, Lo WT, Su MI, Shew JY, Chang TC, Lee WH*., 2013, “A cis-element with mixed G-quadruplex structure of NPGPx promoter is essential for nucleolin-mediated transactivation on non-targeting siRNA stress.”, Nucleic acids research, 41(3), 1533-1543. (SCI) 
Zhu J, Zhou L, Wu G, Konig H, Lin X, Li G, Qiu XL, Chen CF, Hu CM, Goldblatt E, Bhatia R, Chamberlin AR, Chen PL, Lee WH, 2013, “A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.”, EMBO molecular medicine, 5(3), 353-365. (SCI) 
Ngo B, Hu CM, Guo XE, Ngo B, Wei R, Zhu J, Lee WH, 2013, “Complementary Interhelical Interactions between Three Buried Glu-Lys Pairs within Three Heptad Repeats Are Essential for Hec1-Nuf2 Heterodimerization and Mitotic Progression.”, The Journal of biological chemistry, 288(48), 34403-34413. (SCI) 
Wendy W. Hwang-Verslues, Po-Hao Chang, Yung-Ming Jeng, Wen-Hung Kuo, Pei-Hsun Chiang, Yi-Cheng Chang, Tsung-Han Hsieh, Fang-Yi Su, Liu-Chen Lin, Serena Abbondante, Cheng-Yuan Yang, Huan-Ming Hsu, Jyh-Cherng Yu, King-Jen Chang, Jin-Yuh Shew, Eva Y.-H. P. Lee, Wen-Hwa Lee*., 2013, “Loss of corepressor PER2 under hypoxia upregulates OCT1-mediated EMT gene expression and enhances tumor malignancy.”, Proceedings of the national academy of sciences of the United States of America, 110(30), 12331-12336. (SCI) 
He S, Ni D, Ma B, Lee JH, Zhang T, Ghozalli I, Pirooz SD, Zhao Z, Bharatham N, Li B, Oh S, Lee WH, Takahashi Y, Wang HG, Minassian A, Feng P, Deretic V, Pepperkok R, Tagaya M, Yoon HS, Liang C, 2013, “PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex.”, Nature cell biology, 15(10), 1206-1219. (SCI) 
Chang PH, Hwang-Verslues WW, Chang YC, Chen CC, Hsiao M, Jeng YM, Chang KJ, Lee EY, Shew JY*, Lee WH*, 2012, “Activation of Robo1 signaling of breast cancer cells by Slit2 from stromal fibroblast restrains tumorigenesis via blocking PI3K/Akt/beta-catenin pathway.”, Cancer research, 72(18), 4652-4661. (SCI) 
Wei PC, Hsieh YH, Su MI, Jiang X, Hsu PH, Lo WT, Weng JY, Jeng YM, Wang JM, Chen PL, Chang YC, Lee KF, Tsai MD, Shew JY*, Lee WH*, 2012, “Loss of the Oxidative Stress Sensor NPGPx Compromises GRP78 Chaperone Activity and Induces Systemic Disease.”, Molecular cell, 48(5), 747-759. (SCI) 
Chen PL, Chen CF, Chen Y, Guo XE, Huang CK, Shew JY, Reddick RL, Wallace DC, Lee WH, 2012, “Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan.”, Oncogene, 32(9), 1193-1201. (SCI) 
Wei PC, Lo WT, Su MI, Shew JY, Lee WH*., 2012, “Non-targeting siRNA induces NPGPx expression to cooperate with exoribonuclease XRN2 for releasing the stress.”, Nucleic acids research, 40(1), 323-332. (SCI) 
Furuta S, Jeng YM, Zhou L, Huang L, Kuhn I, Bissell MJ, Lee WH, 2011, “IL-25 causes apoptosis of IL-25R-expressing breast cancer cells without toxicity to nonmalignant cells.”, Science translational medicine, 3(78), 78ra31. (SCI) 
Hwang-Verslues WW, Chang PH, Wei PC, Yang CY, Huang CK, Kuo WH, Shew JY, Chang KJ, Lee EY, Lee WH, 2011, “miR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1.”, Oncogene, 30(21), 2463-2474. (SCI) 
Lin LF, Chuang CH, Li CF, Liao CC, Cheng CP, Cheng TL, Shen MR, Tseng JT, Chang WC, Lee WH, Wang JM, 2010, “ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer.”, Cancer research, 70(1), 192-201. (SCI) 
Wu G, Qiu XL, Zhou L, Zhu J, Chamberlin R, Lau J, Chen PL, Lee WH, 2008, “Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.”, Cancer research, 68(20), 8393-9. (SCI) 
Furuta S, Wang JM, Zeng WS, Jeng YM, Jiang Xzi, Gu BN, Chen PL, Lee EY, Lee WH , 2006, “Inactivation of BRCA1/CtIP tumor suppressors releases ANG1 repression mediated by ZBRK1 and leads to pronounced vasculature and growth of breast tumor.”, Cancer Cell, 10: 13-24. 
Poole AJ, Li Y, Kim Y, Lin SC, Lee WH, Lee EY, 2006, “Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist.”, Science, 314(5804), 1467-70. (SCI) 
Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng N, Chen PL, Lee WH, Pavletich NP, 2002, “BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.”, SCIENCE, 297(5588), 1837-48. (SCI) 
Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, Lee EY, Lee WH, 2000, “Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response.”, Nature, 406(6792), 210-5. (SCI) 
Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH, 2000, “Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1.”, Molecular cell, 6(4), 757-68. (SCI) 
Zhong Q, Chen CF, Li S, Chen Y, Wang CC, Xiao J, Chen PL, Sharp ZD, Lee WH, 1999, “Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.”, SCIENCE, 285(5428), 747-50. (SCI) 
Utomo AR, Nikitin AY, Lee WH, 1999, “Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice.”, Nature biotechnology, 17(11), 1091-6. (SCI) 
Riley DJ, Nikitin AY, Lee WH, 1996, “Adenovirus-mediated retinoblastoma gene therapy suppresses spontaneous pituitary melanotroph tumors in Rb+/- mice.”, Nature medicine, 2(12), 1316-21. (SCI) 
Chen Y, Chen CF, Riley DJ, Allred DC, Chen PL, Von Hoff D, Osborne CK, Lee WH, 1995, “Aberrant subcellular localization of BRCA1 in breast cancer.”, Science, 270(5237), 789-91. (SCI) 
Goodrich DW, Lee WH, 1992, “Abrogation by c-myc of G1 phase arrest induced by RB protein but not by p53.”, Nature, 360(6400), 177-9. (SCI) 
Lee EY, Chang CY, Hu N, Wang YC, Lai CC, Herrup K, Lee WH, Bradley A, 1992, “Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis.”, Nature, 359(6393), 288-94. (SCI) 
Huang S, Lee WH, Lee EY, 1991, “A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product.”, Nature, 350(6314), 160-2. (SCI) 
Goodrich DW, Wang NP, Qian YW, Lee EY, Lee WH, 1991, “The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle.”, Cell, 67(2), 293-302. (SCI) 
Chen PL, Chen YM, Bookstein R, Lee WH, 1990, “Genetic mechanisms of tumor suppression by the human p53 gene.”, Science, 250(4987), 1576-80. (SCI) 
Bookstein R, Shew JY, Chen PL, Scully P, Lee WH, 1990, “Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.”, Science, 247(4943), 712-5. (SCI) 
Chen PL, Scully P, Shew JY, Wang JY, Lee WH, 1989, “Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation.”, Cell, 58(6), 1193-8. (SCI) 
Ludlow JW, DeCaprio JA, Huang CM, Lee WH, Paucha E, Livingston DM, 1989, “SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family.”, Cell, 56(1), 57-65. (SCI) 
Lee EY, To H, Shew JY, Bookstein R, Scully P, Lee WH, 1988, “Inactivation of the retinoblastoma susceptibility gene in human breast cancers.”, Science, 241(4862), 218-21. (SCI) 
Huang HJ, Yee JK, Shew JY, Chen PL, Bookstein R, Friedmann T, Lee EY, Lee WH, 1988, “Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells.”, Science, 242(4885), 1563-6. (SCI) 
DeCaprio JA, Ludlow JW, Figge J, Shew JY, Huang CM, Lee WH, Marsilio E, Paucha E, Livingston DM, 1988, “SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene.”, Cell, 54(2), 275-83. (SCI) 
Lee WH, Bookstein R, Hong F, Young LJ, Shew JY, Lee EY, 1987, “Human retinoblastoma susceptibility gene: cloning, identification, and sequence.”, Science, 235(4794), 1394-9. (SCI) 
Lee WH, Shew JY, Hong FD, Sery TW, Donoso LA, Young LJ, Bookstein R, Lee EY, 1987, “The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity.”, Nature, 329(6140), 642-5. (SCI) 
Lee WH, Murphree AL, Benedict WF, 1984, “Expression and amplification of the N-myc gene in primary retinoblastoma.”, Nature, 309(5967), 458-60. (SCI)